Target validation using in-cell small molecule clickable imaging probes-Reference-Cited by-同舟云学术

Target validation using in-cell small molecule clickable imaging probes

Published:2014 Issue:3 Volume:5 Page:247-254
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Ghosh Brahma¹²³⁴,Jones Lyn H.¹⁵⁶⁷⁸

Affiliation:

1. Pfizer

2. WCM-Global Science & Technology

3. Andover

4. USA

5. Chemical Biology Group

6. BioTherapeutics Chemistry

7. WorldWide Medicinal Chemistry

8. Cambridge

Abstract

The application of click chemistry to the visualization of chemical probes in in-cell chemical biology experiments is reviewed and the influence this research has had on target validation and molecular mode of action studies is also highlighted.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C3MD00277B

Reference71 articles.

1. Getting pharmaceutical R&D back on target

2. Target validation using chemical probes

3. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

4. Chemical Tools for Biomolecular Imaging

5. Marked small molecule libraries: a truncated approach to molecular probe design

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