Reactivity-based chemical-genetic study of protein kinases-Reference-Cited by-同舟云学术

Reactivity-based chemical-genetic study of protein kinases

Published:2022 Issue:7 Volume:13 Page:783-797
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Rezende Miranda Renata¹²^ORCID,Zhang Chao¹³^ORCID

Affiliation:

1. Department of Chemistry, Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California, 90089, USA

2. Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, New York, 14623, USA

3. USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, 90089, USA

Abstract

In this review, we describe the development and application of chemical-genetic strategies that feature the use of covalent inhibitors targeting cysteine residues to dissect the cellular functions of individual protein kinases.

Funder

National Science Foundation

American Cancer Society

University of Southern California

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00389E

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4. Exploring the roles of protein kinases using chemical genetics

5. Ten things you should know about protein kinases: IUPHAR Review 14

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