Highly enantio- and diastereoselective construction of spirocyclic oxindoles <i>via</i> a palladium-catalyzed decarboxylative asymmetric [4 + 2] annulation strategy-Reference-Cited by-同舟云学术

Highly enantio- and diastereoselective construction of spirocyclic oxindoles via a palladium-catalyzed decarboxylative asymmetric [4 + 2] annulation strategy

Published:2024 Issue:22 Volume:22 Page:4466-4471
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

You Pengyuan¹²³,Liu Minjie²³,Zhang Ke²³,Yang Fan¹²³,Tan Zequn¹²³,Chen Fener¹²³^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Zhengzhou University, Zhengzhou 450001, China

2. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, 200433 Shanghai, China

3. Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs, 200433, Shanghai, China

Abstract

We developed an asymmetric [4 + 2] annulation reaction of methyleneindolinones with precursors of oxo-1,4-dipole, for which geometric purity of methyleneindolinones was not necessary.

Funder

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00518J

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