Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide-Reference-Cited by-同舟云学术

Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide

Published:2021 Issue:22 Volume:8 Page:6279-6299
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Cornil Johan¹,Hu Zhaoyu¹,Bouchet Marion¹,Mulard Laurence A.¹^ORCID

Affiliation:

1. Unité de Chimie des Biomolécules, Institut Pasteur, UMR3523 CNRS, 28 rue du Dr Roux, 75 724 Paris Cedex 15, France

Abstract

Fine-tuned catalytic processes facilitating regio- and stereoselective conversions for the large-scale synthesis of a pentasaccharide and its oligomerization into ready-for-conjugation haptens.

Funder

European Commission

Institut Pasteur

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D1QO00761K

Reference71 articles.

1. Oligosaccharide Synthesis and Translational Innovation

2. “One-Pot” Protection, Glycosylation, and Protection–Glycosylation Strategies of Carbohydrates