Iron-catalysed alkene and heteroarene H/D exchange by reversible protonation of iron-hydride intermediates-Reference-Cited by-同舟云学术

Iron-catalysed alkene and heteroarene H/D exchange by reversible protonation of iron-hydride intermediates

Published:2022 Issue:35 Volume:13 Page:10291-10298
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Britton Luke¹,Docherty Jamie H.¹^ORCID,Sklyaruk Jan¹,Cooney Jessica¹,Nichol Gary S.¹^ORCID,Dominey Andrew P.²,Thomas Stephen P.¹^ORCID

Affiliation:

1. EaStCHEM School of Chemistry, University of Edinburgh, Edinburgh EH9 3FJ, UK

2. GSK Medicines Research Centre, Stevenage SG1 2NY, UK

Abstract

The iron-catalysed C(sp2)–H bond H/D exchange reaction using CD3OD is reported for both heterocycles and alkenes. Characterisation of the key C–H metallation intermediates provided evidence for reversible protonation of the iron hydride catalyst.

Funder

The Royal Society

Engineering and Physical Sciences Research Council

University of Edinburgh

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC03802A

Reference58 articles.

1. Direct transition metal-catalyzed functionalization of heteroaromatic compounds