Direct electrochemical hydrodefluorination of trifluoromethylketones enabled by non-protic conditions-Reference-Cited by-同舟云学术

Direct electrochemical hydrodefluorination of trifluoromethylketones enabled by non-protic conditions

Published:2021 Issue:30 Volume:12 Page:10252-10258
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Box John R.¹²³⁴^ORCID,Atkins Alexander P.¹²³⁴,Lennox Alastair J. J.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. University of Bristol

3. Bristol

4. UK

Abstract

The electrochemical hydrodefluorination of trifluoromethylketones under non-protic conditions make this single-step reaction at deeply reductive potentials uniquely amenable to challenging electron-rich substrates and reductively sensitive functionalities.

Funder

Royal Society

Syngenta International

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01574E

Reference51 articles.

1. CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?