A simple polystyrene microfluidic device for sensitive and accurate SERS-based detection of infection by malaria parasites-Reference-Cited by-同舟云学术

A simple polystyrene microfluidic device for sensitive and accurate SERS-based detection of infection by malaria parasites

Published:2023 Issue:17 Volume:148 Page:4053-4063
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Oliveira Maria João¹²³^ORCID,Caetano Soraia⁴,Dalot Ana¹²³,Sabino Filipe¹²³,Calmeiro Tomás R.¹^ORCID,Fortunato Elvira¹^ORCID,Martins Rodrigo¹^ORCID,Pereira Eulália⁵^ORCID,Prudêncio Miguel⁴^ORCID,Byrne Hugh J.⁶^ORCID,Franco Ricardo²³^ORCID,Águas Hugo¹^ORCID

Affiliation:

1. CENIMAT-i3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa, and CEMOP/UNINOVA, 2829-516 Caparica, Portugal

2. Associate Laboratory i4HB – Institute for Health and Bioeconomy, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal

3. UCIBIO – Applied Molecular Biosciences Unit, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal

4. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal

5. LAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal

6. FOCAS Research Institute, Technological University Dublin, Camden Street, Dublin 8, Ireland

Abstract

Novel microfluidic SERS immunoassay to detect Plasmodium falciparum (Pf), with a LOD of 0.0012 ± 0.0001% parasitaemia, equivalent to ≈69 parasites per μL, a ∼7-fold higher sensitivity than most Malaria rapid diagnostic tests.

Funder

Fundação para a Ciência e a Tecnologia

H2020 European Research Council

“la Caixa” Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/AN/D3AN00971H

Reference57 articles.

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