Enantiodivergent biosynthesis of β-hydroxy esters by self-sufficient heterogeneous biocatalysts in a continuous flow

Author:

Andrés-Sanz Daniel1ORCID,Maiz-Iginitz Ainhoa12ORCID,Bolivar Juan M.3ORCID,Orrego Alejandro H.1ORCID,Sardon Haritz2ORCID,López-Gallego Fernando14ORCID

Affiliation:

1. Heterogeneous Biocatalysis Laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramón 182, Donostia San Sebastián, Spain

2. POLYMAT and Department of Polymers and Advanced Materials: Physics, Chemistry and Technology, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel de Lardizábal, 3, 20018 Donostia-San Sebastián, Spain

3. FQPIMA Group Department of Chemical Engineering, Complutense University of Madrid, Madrid, Spain

4. IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain

Abstract

Developing two self-sufficient heterogeneous biocatalysts to synthesise enantiopure β-hydroxy esters in continuous flow. Operational conditions are tuned to maximise the productivity and stability of biocatalytic packed-bed reactors.

Funder

Eusko Jaurlaritza

Ikerbasque, Basque Foundation for Science

Agencia Estatal de Investigación

Publisher

Royal Society of Chemistry (RSC)

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