On the Brønsted acid-catalyzed aza-Michael reaction of isoxazol-5-ones to enones: reaction optimization, scope, mechanistic investigations and scale-up

Author:

de Siqueira Marcelo M.1,de Castro Pedro P.2ORCID,dos Santos Juliana A.1,Flores Leonã S.1,de Paiva Walysson F.3ORCID,Fernandes Sergio A.3,Amarante Giovanni W.1ORCID

Affiliation:

1. Chemistry Department, Federal University of Juiz de Fora, Campus Martelos, Juiz de Fora, Minas Gerais, 36036-900, Brazil

2. Chemistry Department, Federal University of São Carlos, São Carlos, São Paulo, 13565-905, Brazil

3. Chemistry Department, Federal University of Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil

Abstract

Regioselective aza-Michael-type of isoxazol-5-ones to activate double bonds.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

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