Metal-free synthesis of an estetrol key intermediate under intensified continuous flow conditions
Author:
Affiliation:
1. Center for Integrated Technology and Organic Synthesis, MolSys Research Unit, University of Liège, B-4000 Liège (Sart Tilman), Belgium
2. Mithra Pharmaceuticals, B-4000 Liège, Belgium
3. Ehrfeld Mikrotechnik GmbH, 55234 Wendelsheim, Germany
Abstract
Funder
Fonds De La Recherche Scientifique - FNRS
Publisher
Royal Society of Chemistry (RSC)
Subject
Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00051F
Reference62 articles.
1. Estetrol: A New Choice for Contraception
2. Synthesis of estra-1,3,5(10)-trien-3,15α,16α,17β-tetrol a new metabolite of estradiol
3. Synthesis of epimeric 15-hydroxyestriols, new and potential metabolites of estradiol
4. Estetrol (E4): the new estrogenic component of combined oral contraceptives
5. Profile of estetrol, a promising native estrogen for oral contraception and the relief of climacteric symptoms of menopause
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