A peculiar dehydration and solid–solid phase transition of the active pharmaceutical ingredient AZD9898 based on in situ single crystal-to-single crystal transformations-Reference-Cited by-同舟云学术

A peculiar dehydration and solid–solid phase transition of the active pharmaceutical ingredient AZD9898 based on in situ single crystal-to-single crystal transformations

Published:2020 Issue:43 Volume:22 Page:7280-7289
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Pettersen Anna¹²³⁴⁵^ORCID,Putra Okky Dwichandra⁶⁷⁴⁵⁸^ORCID,Light Mark E.⁹¹⁰¹¹¹²¹³,Namatame Yukiko¹⁴¹⁵¹⁶

Affiliation:

1. Early Product Development and Manufacturing

2. Pharmaceutical Sciences

3. BioPharmaceuticals R&D

4. AstraZeneca Gothenburg

5. Mölndal SE-431 83

6. New Modality and Parenteral Development

7. Pharmaceutical Technology and Development

8. Sweden

9. UK National Crystallography Service

10. School of Chemistry

11. Faculty of Engineering and Physical Sciences

12. University of Southampton

13. SO17 1BJ Southampton

14. Rigaku Corporation

15. Tokyo 196-8666

16. Japan

Abstract

Isostructural dehydration from form A hydrate to form B, and solid–solid phase transition from form B to C of AZD9898 were revealed by in situ single crystal-to-single crystal transformations.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CE/D0CE00276C

Reference39 articles.

1. Theoretical approaches to physical transformations of active pharmaceutical ingredients during manufacturing processes

2. Solubility Improvement of Benexate through Salt Formation Using Artificial Sweetener

3. Capturing a new hydrate polymorph of amodiaquine dihydrochloride dihydrate via heterogeneous crystallisation

4. Solubility improvement of epalrestat by layered structure formation via cocrystallization

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