Characterization of a LanC-free pathway for the formation of an <scp>ll</scp>-MeLan residue and an <i>allo</i>AviMeCys residue in the newly identified class V lanthipeptide triantimycins-Reference-Cited by-同舟云学术

Characterization of a LanC-free pathway for the formation of an ll-MeLan residue and an alloAviMeCys residue in the newly identified class V lanthipeptide triantimycins

Published:2024 Issue:24 Volume:15 Page:9266-9273
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ding Weizhong¹,Wang Xiaofeng¹²,Yin Yu³,Tao Jiang⁴,Xue Yanqing¹^ORCID,Liu Wen¹

Affiliation:

1. State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

2. School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sublane Xiangshan, Hangzhou 310024, China

3. Shanghai Jiao Tong University, Shanghai 200240, China

4. Department of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Science, No. 639 Zhizaoju Road, Shanghai 200011, China

Abstract

The cyclization step of lanthionines is typically catalyzed by a LanC cyclase or a cyclase domain. Here, we report a LanC-free pathway for the formation of an ll-MeLan residue and a stereochemically diverse alloAviMeCys residue in triantimycins.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC02302A

Reference39 articles.

1. New developments in RiPP discovery, enzymology and engineering

2. Discovery of phosphorylated lantibiotics with proimmune activity that regulate the oral microbiome

3. Mammalian Commensal Streptococci Utilize a Rare Family of Class VI Lanthipeptide Synthetases to Synthesize Miniature Lanthipeptide-type Ribosomal Peptide Natural Products

4. The First Lanthipeptide from Lactobacillus iners, Inecin L, Exerts High Antimicrobial Activity against Human Vaginal Pathogens

5. Discovery and biosynthesis of tricyclic copper-binding ribosomal peptides containing histidine-to-butyrine crosslinks