Alkoxyallene-based syntheses of preussin and its analogs and their cytotoxicity
Author:
Affiliation:
1. Institut für Chemie und Biochemie
2. Freie Universität Berlin
3. 14195 Berlin
4. Germany
5. Bayer AG
6. Research & Development
7. 13353 Berlin
Abstract
Preussin made in Prussia!Axially chiral alkoxyallenes provided oxa-preussin, racemic and enantiopure (−)-preussin (cytotoxicities: IC50= 3–6 μM).
Funder
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02645A
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