Syntheses of deuterium-labeled dihydroartemisinic acid (DHAA) isotopologues and mechanistic studies focused on elucidating the conversion of DHAA to artemisinin-Reference-Cited by-同舟云学术

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Syntheses of deuterium-labeled dihydroartemisinic acid (DHAA) isotopologues and mechanistic studies focused on elucidating the conversion of DHAA to artemisinin

Published:2024 Issue: Volume: Page:
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Varela Kaitlyn¹^ORCID,Yoshimoto Francis K.¹^ORCID

Affiliation:

1. Department of Chemistry, The University of Texas San Antonio (UTSA), One UTSA Circle, San Antonio, TX 78249-0698, USA

Abstract

Artemisia annua is a plant that produces dihydroartemisinic acid (DHAA), which undergoes a reaction with two molecules of O2 to yield artemisinin, an endoperoxide-containing sesquiterpenoid used to treat malaria.

Funder

Ford Foundation Fellowships

Grand Challenges in Global Health

National Science Foundation Graduate Research Fellowship Program

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00777H

Reference55 articles.

1. Isolation and Identification of Dihydroartemisinic Acid from Artemisia annua and Its Possible Role in the Biosynthesis of Artemisinin

2. Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy

3. Reaction of antimalarial endoperoxides with specific parasite proteins

4. Artemisinin: A Case Study in the Evolution of Synthetic Strategy

5. Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

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