Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway-Reference-Cited by-同舟云学术

Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway

Published:2021 Issue:18 Volume:12 Page:8800-8811
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Luo Man¹²,Zheng Lian-Wen³,Wang Yu-Si¹,Huang Ji-Cheng¹,Yang Zhan-Qing¹,Yue Zhan-Peng¹,Guo Bin¹^ORCID

Affiliation:

1. College of Veterinary Medicine, Jilin University, Changchun, P. R. China

2. Department of Obstetrics and Gynecology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, P. R. China

3. Reproductive Medical Center, Jilin University Second Hospital, Changchun, P. R. China

Abstract

GEN exhibited therapeutic potential for PCOS mice by enhancing the antioxidant capability and preventing the mitochondrial dysfunction dependent on the ER-Nrf2-Foxo1 pathway.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China Stem Cell and Translational Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO00684C

Reference33 articles.

1. PCOS in Adolescence and Type 2 Diabetes

2. Cardiometabolic Risk in PCOS: More than a Reproductive Disorder

3. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

4. The phytoestrogen genistein promotes wound healing by multiple independent mechanisms

5. An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health

Cited by 33 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Eicosatrienoic acid inhibits estradiol synthesis through the CD36/FOXO1/CYP19A1 signaling pathway to improve PCOS in mice;Biochemical Pharmacology;2024-11

2. SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis;Biochimica et Biophysica Acta (BBA) - Molecular Cell Research;2024-10

3. Wine- and stir-frying processing of Cuscutae Semen enhance its ability to alleviate oxidative stress and apoptosis via the Keap 1-Nrf2/HO-1 and PI3K/AKT pathways in H2O2-challenged KGN human granulosa cell line;BMC Complementary Medicine and Therapies;2024-05-15

4. Osthole exhibits the remedial potential for polycystic ovary syndrome mice through Nrf2‐Foxo1‐GSH‐NF‐κB pathway;Cell Biology International;2024-05-13

5. Role of nuclear factor erythroid 2-related factor 2 (Nrf2) in female and male fertility;Heliyon;2024-05