Bioactive cell niche mediating uniform thermal stimulus for BMSC neural differentiation through TRPV1 channel activation

Author:

Dan Wei 1,Zeng Mingze1,Su Borui1,Zhang Yusheng1,Wu Kai1,Zhou Ting1,Wu Chengheng12ORCID,Sun Jing1,Fan Hongsong1ORCID

Affiliation:

1. National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, Sichuan, China

2. Institute of Regulatory Science for Medical Devices, Sichuan University, Chengdu 610065, Sichuan, China

Abstract

By incorporating photothermal dopamine domains into hyaluronic acid chains, a biomimetic photothermal hydrogel with matrix-mediated homogeneous thermal stimulus is obtained for promoting neural differentiation of BMSCs under remote light stimulus.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Natural Science Foundation of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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