The structure of isolated thalidomide as reference for its chirality-dependent biological activity: a laser-ablation rotational study-Reference-Cited by-同舟云学术

The structure of isolated thalidomide as reference for its chirality-dependent biological activity: a laser-ablation rotational study

Published:2021 Issue:24 Volume:23 Page:13705-13713
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Blanco Susana¹²³⁴⁵^ORCID,Macario Alberto¹²³⁴⁵^ORCID,López Juan Carlos¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Química Física y Química Inorgánica

2. Facultad de Ciencias

3. IU CINQUIMA

4. Universidad de Valladolid

5. 47011 Valladolid

Abstract

Using the gas-phase structure of laser-ablated thalidomide as reference confirms the high distortion of the (R)-enantiomer bound to cereblon in agreement with the enhanced teratogenicity of the (S) enantiomer.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP01691A

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5. Treatment of multiple myeloma

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