Recent advances in the biosynthesis of unusual polyketide synthase substrates-Reference-Cited by-同舟云学术

Recent advances in the biosynthesis of unusual polyketide synthase substrates

Published:2016 Issue:2 Volume:33 Page:150-161
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Ray Lauren¹²³⁴,Moore Bradley S.¹²³⁴⁵

Affiliation:

1. Scripps Institution of Oceanography

2. University of California at San Diego

3. La Jolla

4. USA

5. Skaggs School of Pharmacy and Pharmaceutical Sciences

Abstract

Polyketides comprise a diverse class of natural products, with many important biological and pharmacological activities. Substrates functioning as starter units and extender units during their assembly significantly contribute to the chemical complexity exhibited by this class of natural products. This highlight provides an overview of the recent advances in understanding the diversity of these polyketide synthase (PKS) building blocks.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/NP/C5NP00112A

Reference69 articles.

1. Polyketide biosynthesis: a millennium review

2. Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms

3. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork