Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers-Reference-Cited by-同舟云学术

Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers

Published:2015 Issue:40 Volume:13 Page:10150-10154
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Glaffig M.¹²³⁴,Palitzsch B.¹²³⁴,Stergiou N.⁵⁶¹⁷⁴,Schüll C.¹²³⁴,Straßburger D.¹²³⁴,Schmitt E.⁵⁶¹⁷⁴,Frey H.¹²³⁴,Kunz H.¹²³⁴

Affiliation:

1. Johannes Gutenberg-University Mainz

2. Institute of Organic Chemistry

3. 55128 Mainz

4. Germany

5. University Medical Center

6. Institute of Immunology

7. 55101 Mainz

Abstract

A fully synthetic multivalent MUC1 glycopeptide vaccine based on a hyperbranched polyglycerol core induced IgG antibodies which strongly recognise epithelial tumour cells.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01255D

Reference31 articles.

1. A Fully Synthetic Glycopeptide Antitumor Vaccine Based on Multiple Antigen Presentation on a Hyperbranched Polymer

2. MUC1: A target molecule for cancer therapy

3. MUC1 and cancer

4. A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas

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