Mechanism for the enhanced reactivity of 4-mercaptoprolyl thioesters in native chemical ligation-Reference-Cited by-同舟云学术

Mechanism for the enhanced reactivity of 4-mercaptoprolyl thioesters in native chemical ligation

Published:2016 Issue:72 Volume:6 Page:68312-68321
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ali Shah Muhammad Ishaq¹²³⁴,Xu Zhe-Yuan⁵⁶¹⁷⁸,Liu Lei¹²³⁴,Jiang Yuan-Ye⁵⁶¹⁷⁸,Shi Jing⁵⁶¹⁷⁸

Affiliation:

1. Department of Chemistry

2. Tsinghua University

3. Beijing 100084

4. China

5. Collaborative Innovation Center of Chemistry for Energy Materials

6. CAS Key Laboratory of Urban Pollutant Conversion

7. University of Science and Technology of China

8. Hefei 230026

Abstract

Ring-strain-precluded strategy benefiting from entropy effects and n → π* orbital interaction, enhances the reactivity of C-terminal prolyl thioesters in NCL.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA13793H

Reference92 articles.

1. Total chemical synthesis of proteins

2. Sequential native peptide ligation strategies for total chemical protein synthesis

3. Chemical Synthesis and Biological Function of Lipidated Proteins

4. Chemical Methods for Protein Ubiquitination

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