Engineering 3D-printed core–shell hydrogel scaffolds reinforced with hybrid hydroxyapatite/polycaprolactone nanoparticles for in vivo bone regeneration

Author:

El-Habashy Salma E.12345ORCID,El-Kamel Amal H.12345ORCID,Essawy Marwa M.67345ORCID,Abdelfattah Elsayeda-Zeinab A.8345,Eltaher Hoda M.12345ORCID

Affiliation:

1. Department of Pharmaceutics

2. Faculty of Pharmacy

3. Alexandria University

4. Alexandria

5. Egypt

6. Oral Pathology Department

7. Faculty of Dentistry

8. Medical Research Institute (MRI)

Abstract

3D-printed biphasic core/shell hydrogel scaffolds with hybrid bioactive nanoparticles reinforcing core phase possessed controlled swelling, mechanical stiffness and dual-ranged pore size. They provided prominent osteoconductivity, biocompatibility and in-vivo osteogenicity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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