Structural analysis of metastable pharmaceutical loratadine form II, by 3D electron diffraction and DFT+D energy minimisation-Reference-Cited by-同舟云学术

Structural analysis of metastable pharmaceutical loratadine form II, by 3D electron diffraction and DFT+D energy minimisation

Published:2020 Issue:43 Volume:22 Page:7490-7499
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Woollam Grahame R.¹²³^ORCID,Das Partha P.⁴⁵⁶^ORCID,Mugnaioli Enrico⁷⁸⁹¹⁰^ORCID,Andrusenko Iryna⁷⁸⁹¹⁰^ORCID,Galanis Athanassios S.⁴⁵⁶,van de Streek Jacco¹¹¹²¹³^ORCID,Nicolopoulos Stavros⁴⁵⁶,Gemmi Mauro⁷⁸⁹¹⁰^ORCID,Wagner Trixie¹⁴²³

Affiliation:

1. Novartis Pharma AG

2. Basel 4002

3. Switzerland

4. NanoMegas

5. B1080 Brussels

6. Belgium

7. Center for Nanotechnology Innovation@NEST

8. Istituto Italiano di Tecnologia

9. 56127 Pisa

10. Italy

11. Avant-garde Materials Simulation

12. Merzhausen

13. Germany

14. Novartis Institutes for BioMedical Research

Abstract

Coupling 3D electron diffraction and density functional theory provided the metastable pharmaceutical crystal structure within nanometre range, under ambient conditions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CE/D0CE01216E

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