In vitrocharacterization of a novel C,N-cyclometalated benzimidazole Ru(ii) arene complex: stability, intracellular distribution and binding, effects on organic osmolyte homeostasis and induction of apoptosis-Reference-Cited by-同舟云学术

In vitrocharacterization of a novel C,N-cyclometalated benzimidazole Ru(ii) arene complex: stability, intracellular distribution and binding, effects on organic osmolyte homeostasis and induction of apoptosis

Published:2015 Issue:5 Volume:7 Page:885-895
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Støving Dam Celina¹²³¹⁴,Alejo Perez Henarejos Sergio⁵⁶⁷,Tsolakou Theodosia¹²³¹⁴,Alexander Segato Christian¹⁴³,Gammelgaard Bente¹²³,Yellol Gorakh S.⁵⁶⁷,Ruiz José⁵⁶⁷,Henry Lambert Ian¹⁴³,Stürup Stefan¹²³

Affiliation:

1. University of Copenhagen

2. Department of Pharmacy

3. 2100 Copenhagen Ø, Denmark

4. Department of Biology

5. Department of Inorganic Chemistry and Regional Campus of International Excellence “Campus Mare Nostrum”

6. University of Murcia and Institute for Bio-Health Research of Murcia IMIB-Arrixaca

7. E-30071 Murcia, Spain

Abstract

Applying a novel protocol for the characterization of metal-based drugs reveals the potential of a new Ru-based compound in overcoming Cisplatin resistance.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MT/C5MT00056D

Reference29 articles.

1. World Health Organization, http://www.who.int/mediacentre/factsheets/fs297/en/ , accessed January 2015

2. Cisplatin in cancer therapy: Molecular mechanisms of action

3. Molecular mechanisms of cisplatin resistance

4. Molecular mechanisms of resistance and toxicity associated with platinating agents

5. On the antitumor properties of novel cyclometalated benzimidazole Ru(ii), Ir(iii) and Rh(iii) complexes

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