Fabrication and characterization of optogenetic, multi-strip cardiac muscles

Author:

Chan Vincent1234,Neal Devin M.1234,Uzel Sebastien G. M.1234,Kim Hyeonyu1234,Bashir Rashid56789,Asada H. Harry1234

Affiliation:

1. Department of Mechanical Engineering

2. Massachusetts Institute of Technology

3. Cambridge

4. USA 02139

5. Department of Bioengineering

6. Micro and Nanotechnology Laboratory

7. University of Illinois at Urbana-Champaign

8. Urbana

9. USA 61801

Abstract

We demonstrate a novel technique to construct parallel assemblies of smaller muscle strips that maximize the volume of active muscle layers. In tandem with multiple muscle strips, external control through the use of optogenetics can selectively recruit muscle strips for the gradation of these forces.

Funder

National Science Foundation

Singapore-MIT Alliance for Research and Technology Centre

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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