Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities-Reference-Cited by-同舟云学术

Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

Published:2014 Issue:3 Volume:31 Page:335-355
ISSN:0265-0568
Container-title:Nat. Prod. Rep.
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Rohena Cristina C.¹²,Mooberry Susan L.¹²³⁴

Affiliation:

1. University of Texas Health Science Center at San Antonio

2. San Antonio, USA

3. Cancer Therapy Research Center

4. San Antonio, TX USA

Abstract

Nature has provided a diverse array of microtubule stabilizers. Marine, plant and microbial derived microtubule stabilizers of highly divergent chemical structures, interact with tubulin to cause microtubule stabilization and bundling.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/NP/C3NP70092E

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1. Mitosis is not a key target of microtubule agents in patient tumors

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