Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway-Reference-Cited by-同舟云学术

Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway

Published:2015 Issue:2 Volume:6 Page:1018-1026
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Porter Meghan R.¹²³⁴,Kochi Akiko¹⁵⁶⁴¹,Karty Jonathan A.¹²³⁴,Lim Mi Hee¹⁷⁸⁹¹⁰,Zaleski Jeffrey M.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Indiana University

3. Bloomington

4. USA

5. University of Michigan

6. Ann Arbor

7. Ulsan National Institute of Science and Technology (UNIST)

8. Ulsan 689-798

9. Korea

10. Life Sciences Institute

Abstract

We demonstrate that ligand–metal–Aβ interaction with subsequent radical generation is a relatively rapid mechanism for influencing Aβ structural integrity and thus, the aggregation pathway.

Funder

Directorate for Mathematical and Physical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C4SC01979B

Reference94 articles.

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5. The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer’s Disease

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