A concise total synthesis of cochlearoid B
Author:
Affiliation:
1. Key Laboratory of Synthetic Rubber
2. Chinese Academy of Sciences
3. Changchun 130022
4. China
5. Green Chemistry and Process Laboratory
Abstract
A T-type calcium channel inhibiting natural product cochlearoid B was synthesized in 7 linear steps.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00615F
Reference30 articles.
1. Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear
2. Ganoderma – A therapeutic fungal biofactory
3. T-type calcium channels blockers as new tools in cancer therapies
4. The Role of T-Type Calcium Channels in Epilepsy and Pain
5. State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects
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