Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions-Reference-Cited by-同舟云学术

Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions

Published:2022 Issue:52 Volume:58 Page:7277-7280
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

del Río-Rodríguez Roberto¹^ORCID,Westwood Matthew T.²^ORCID,Sicignano Marina¹^ORCID,Juhl Martin²^ORCID,Fernández-Salas Jose A.¹³^ORCID,Alemán José¹³⁴^ORCID,Smith Andrew D.²^ORCID

Affiliation:

1. Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, 28049-Madrid, Spain

2. EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, Fife, Scotland, KY16 9ST, UK

3. Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain

4. Center for Innovation in Advanced Chemistry (ORFEO-CINQA), Universidad Autónoma de Madrid, 28049, Madrid, Spain

Abstract

The photocatalytic generation of α-amino radicals is combined with chiral isothiourea derived α,β-unsaturated acyl ammonium intermediates to generate γ-lactams in good yields and enantioselectivities under batch and flow conditions.

Funder

Carlsbergfondet

Comunidad de Madrid

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC02432B

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