Metal-free β,γ-C(sp<sup>3</sup>)–H difunctionalization of propanols: DMP-initiated asymmetric spirocyclopropanation-Reference-Cited by-同舟云学术

Metal-free β,γ-C(sp³)–H difunctionalization of propanols: DMP-initiated asymmetric spirocyclopropanation

Published:2024 Issue:26 Volume:60 Page:3579-3582
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Li Zheyao¹,Zhang Huiwen¹,Zhao Lin¹,Ma Yueyue²,Wu Qiufang¹,Ren Haosong¹,Lin Zhongren¹,Zheng Jun¹^ORCID,Yu Xinhong¹^ORCID

Affiliation:

1. Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy and State Key Laboratory of Bioengineering Reactors, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

2. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, 100 West Waihuan Road, Guangzhou 510006, Guangdong, China

Abstract

This work reports a one-pot asymmetric synthesis of spirocyclopropyl propionaldehydes/propanols via β,γ-bifunctionalization of propanols through the synergistic effect of a secondary amine catalyst and an oxidant.

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC00116H

Reference41 articles.

1. Syntheses and Applications of Spirocyclopropyl Oxindoles: A Decade Review

2. DABCO-Catalyzed Michael/Alkylation Cascade Reactions Involving α-Substituted Ammonium Ylides for the Construction of Spirocyclopropyl Oxindoles: Access to the Powerful Chemical Leads against HIV-1

3. Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: Success and challenges

4. Synthesis of Cyclopropanes via Hydrogen-Borrowing Catalysis

5. Spirocyclopropyl carbohydrates: Synthesis and applications

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Organocatalytic [3+2] Annulation of β-Tetralones with α,β-Unsaturated Aldehydes;Synlett;2024-05-03