Drug-guided screening for pancreatic lipase inhibitors in functional foods-Reference-Cited by-同舟云学术

Drug-guided screening for pancreatic lipase inhibitors in functional foods

Published:2021 Issue:10 Volume:12 Page:4644-4653
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Zhang Lujia¹²³⁴⁵^ORCID,Zheng Jinkai⁶⁷⁸⁵,Ma Mingzhe¹²³⁴⁵^ORCID,Zhao Yue¹²³⁴⁵,Song Jia⁹¹⁰¹¹⁵,Chen Xin⁹¹⁰¹¹⁵,Cao Wanxiu⁹¹⁰¹¹⁵^ORCID,He Xiao¹²³⁴⁵^ORCID,Xue Changhu⁹¹⁰¹¹⁵,Tang Qingjuan⁹¹⁰¹¹⁵^ORCID

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development

2. School of Chemistry and Molecular Engineering

3. East China Normal University

4. Shanghai 200062

5. China

6. Institute of Food Science and Technology

7. Chinese Academy of Agricultural Sciences

8. Beijing

9. College of Food Science and Engineering

10. Ocean University of China

11. Qingdao

Abstract

A novel drug-guided screening strategy for safe functional compounds in food. Pancreatic lipase inhibitors derived from natural foods with a similar mechanism to orlistat. 20 potential inhibitors were screened from 57 328 molecules of the CNPD efficiently.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Key Technology Research and Development Program of Shandong

China Postdoctoral Science Foundation

Shanghai Municipal Education Commission

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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