Synthesis and biological evaluation of 1-(2-(adamantane-1-yl)-1H-indol-5-yl)-3-substituted urea/thiourea derivatives as anticancer agents
Author:
Affiliation:
1. Fujian Provincial Key Laboratory of Innovative Drug Target Research
2. School of Pharmaceutical Sciences
3. Xiamen University
4. Xiamen
5. China
Abstract
A series of novel 2,5-disubstituted indole derivatives were synthesized. Compounds 7n, 7s, and 7w induced Nur77-expression in a time- and dose- dependent manner in H460 cells. Furthermore, Nur77 served as a critical mediator for the anticancer action of 7s.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA08149A
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