Redox-responsive dual chemophotothermal therapeutic nanomedicine for imaging-guided combinational therapy

Author:

Yu Fei1234,Zhang Fuwu56789ORCID,Tang Longguang1234,Ma Jingwen101112134,Ling Daishun141516174,Chen Xiaoyuan56789ORCID,Sun Xiaolian101112134ORCID

Affiliation:

1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine

2. School of Public Health

3. Xiamen University

4. China

5. Laboratory of Molecular Imaging and Nanomedicine (LOMIN)

6. National Institute of Biomedical Imaging and Bioengineering (NIBIB)

7. National Institutes of Health

8. Bethesda

9. USA

10. State Key Laboratory of Natural Medicines

11. Department of Pharmaceutical Analysis

12. China Pharmaceutical University

13. Nanjing 210009

14. Zhejiang Province Key Laboratory of Anti-Cancer Drug Research

15. College of Pharmaceutical Sciences

16. Zhejiang University

17. Hangzhou 310058

Abstract

A glutathione-responsive trimeric prodrug with 99% encapsulation efficiency into targeted polymeric nanoparticles is designed for imaging-guided dual chemophotothermal therapy.

Funder

National Natural Science Foundation of China

China Pharmaceutical University

National Institute of Biomedical Imaging and Bioengineering

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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