Highly efficient asymmetric bioreduction of 1-aryl-2-(azaaryl)ethanones. Chemoenzymatic synthesis of lanicemine-Reference-Cited by-同舟云学术

Highly efficient asymmetric bioreduction of 1-aryl-2-(azaaryl)ethanones. Chemoenzymatic synthesis of lanicemine

Published:2019 Issue:35 Volume:17 Page:8214-8220
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liz Ramón¹²³⁴,Liardo Elisa¹²³⁴,Rebolledo Francisca¹²³⁴^ORCID

Affiliation:

1. Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Biotecnología de Asturias

2. Universidad de Oviedo

3. 33006-Oviedo

4. Spain

Abstract

1-Aryl-2-(azaaryl)ethanols with ee > 99% have been prepared by KRED-catalyzed reduction of the ketone precursors. A chemoenzymatic synthesis of lanicemine is described.

Funder

Gobierno del Principado de Asturias

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01616C

Reference42 articles.

1. Asymmetric Synthesis of Active Pharmaceutical Ingredients

2. The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients

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4. Applications of Nonenzymatic Catalysts to the Alteration of Natural Products

5. Optically active bipyridines in nickel catalyzed enantioselective conjugate addition to enones

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