Anticancer auranofin engages 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) as a target
Author:
Affiliation:
1. Department of Chemistry
2. The University of Hong Kong
3. Chemical Biology Centre
4. The Hong Kong Jockey Club Building for Interdisciplinary Research
5. China
6. Department of Chemistry and State Key Laboratory of Synthetic Chemistry
Abstract
Subcellular fractionation method was used with HPLC-MS/MS technique for proteomics analysis to study the anticancer mechanism of action of auranofin. HMGCR is identified as a novel target of auranofin.
Funder
University Grants Committee
Publisher
Oxford University Press (OUP)
Subject
Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2019/MT/C9MT00185A
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