Anticancer auranofin engages 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) as a target-Reference-Cited by-同舟云学术

Anticancer auranofin engages 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) as a target

Published:2019 Issue:11 Volume:11 Page:1925-1936
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Tian Songhai¹²³⁴⁵,Siu Fung-Ming⁶²⁵,Lok Chun-Nam¹²³⁴⁵^ORCID,Fung Yi Man Eva¹²³⁴⁵^ORCID,Che Chi-Ming⁶²⁵^ORCID

Affiliation:

1. Department of Chemistry

2. The University of Hong Kong

3. Chemical Biology Centre

4. The Hong Kong Jockey Club Building for Interdisciplinary Research

5. China

6. Department of Chemistry and State Key Laboratory of Synthetic Chemistry

Abstract

Subcellular fractionation method was used with HPLC-MS/MS technique for proteomics analysis to study the anticancer mechanism of action of auranofin. HMGCR is identified as a novel target of auranofin.

Funder

University Grants Committee

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MT/C9MT00185A

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