Cell-SELEX-based selection of ssDNA aptamers for specifically targeting BRAF V600E-mutated melanoma

Author:

Li Wanming1,Bing Tao2ORCID,Wang Rui3,Jin Sihan1,Shangguan Dihua2ORCID,Chen Hang4ORCID

Affiliation:

1. Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang North New Area, Shenyang 110122, Liaoning, China

2. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, institute of chemistry, Chinese Academy of Sciences, 100190, Beijing, China

3. Department of Stem Cells and Regenerative Medicine, Key Laboratory of Cell Biology, Ministry of Public Health of China, and Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang North New Area, Shenyang 110122, Liaoning, China

4. Experiment Teaching Center of Functional Subjects, College of Basic Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning, China

Abstract

Malignant melanoma is regarded as the most aggressive form of skin cancer, and is responsible for most death caused by skin cancer.

Funder

Natural Science Foundation of Liaoning Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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