A biocompatible process to prepare hyaluronan-based material able to self-assemble into stable nano-particles

Author:

Calce Enrica1234,Ringhieri Paola56784,Mercurio Flavia Anna1234,Leone Marilisa12345,Bugatti Valeria910114,Saviano Michele122134,Vittoria Vittoria910114,De Luca Stefania12345

Affiliation:

1. Institute of Biostructures and Bioimaging

2. National Research Council

3. 80138 Naples

4. Italy

5. Department of Pharmacy

6. Interuniversity Centre for Research on Bioactive Peptides

7. CIRPeB

8. University of Naples “Federico II”

9. Department of Industrial Engineering

10. University of Salerno

11. 84084 Fisciano (Sa)

12. Institute of Crystallography

13. 70126 Bari

Abstract

A microwave-assisted solvent-free process was employed to esterify palmitic, oleic and linoleic acids by hyaluronan alcoholic functions. The obtained HA derivatives were able to form stable spherical nano-sized aggregates, in a range of 63–266 nm.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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