Immobilization ofl-methioninase on a zirconium-based metal–organic framework as an anticancer agent

Author:

Hassabo Amany A.1234,Mousa Amria M.5234ORCID,Abdel-Gawad Hassan67284ORCID,Selim Mohsen H.1234ORCID,Abdelhameed Reda M.67284ORCID

Affiliation:

1. Microbial Chemistry Department

2. National Research Centre

3. Cairo

4. Egypt

5. Biochemistry Department

6. Applied Organic Chemistry Department

7. Chemical Industries Research Division

8. Dokki

Abstract

A new composite (METase@UiO-66) was prepared froml-methioninase and UiO-66-(COOH), which exhibited enhanced thermostability, pH and storage lifetime compared tol-methioninase. Moreover,in vivoexperiments showed that the drug inhibited tumor growth in mice.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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