The α-alkylation of ketones in flow-Reference-Cited by-同舟云学术

The α-alkylation of ketones in flow

Published:2023 Issue:8 Volume:8 Page:1839-1842
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Cooper Ella¹,Alcock Emma¹,Power Mark¹,McGlacken Gerard¹^ORCID

Affiliation:

1. School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, T12 YN60 Cork, Ireland

Abstract

A continuous flow methodology is described which gives α-alkylated ketones in good yields, avoids cryogenic temperatures, excessive exposure to alkyllithiums/alkylhalides, and can be easily and continuously scaled-out (to >3 g in 45 min).

Funder

Irish Research Council

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00229B

Reference32 articles.

1. J. E.McMurry , Organic Chemistry , Cengage Learning , Boston , 2015

2. B. M.Trost and I.Flemming , Comprehensive Organic Synthesis , Paragamon , Amsterdam , 1991

3. J.Plaquevent , D.Cahard , F.Guillen and J.Green , Science of Synthesis , Georg Thieme Verlag , 2005 , vol. 26 , pp. 463–511

4. A. R.Katritzky and R. J. K.Taylor , Comprehensive Organic Functional Group Transformations II , Elsevier , Amsterdam , 2005

5. Lithium Enolates of Simple Ketones: Structure Determination Using the Method of Continuous Variation

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