A cubic Cu2O@Ag bioprobe for label-free SERS classification of hepatic fibrosis and hepatocellular carcinoma

Author:

Xie Yujiao12,Li Xue3,Xu Lei14,Zhang Chenguang1,Ren Yong2ORCID,Shi Xiaofeng3,Fu Liyun3,Wang Jing14,Xu Xiawei1,Liu Yue1,Hu Yue1,Zhang Zhouxu1,Zhang Jiahao1,Yao Ting4,Ren Wenzhi1ORCID,Chen Tianxiang1,Qian Xiaoyu3,Wang Xiaotian5ORCID,Lin Jie1ORCID,Wu Aiguo1ORCID

Affiliation:

1. Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Ningbo Cixi Institute of Biomedical Engineering, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China

2. Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham Ningbo China, Ningbo, China

3. Department of Hepatology, Ningbo No. 2 Hospital and the Affiliated Hospital, Medical School of Ningbo University, Ningbo 315010, China

4. The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou City 310003, China

5. School of Chemistry, Beihang University, Beijing, China

Abstract

In this study, a cubic Cu2O@Ag core–shell substrate for label-free SERS was constructed and machine-learning-assisted linear discriminant analysis was used for identification of hepatic fibrosis and hepatocellular carcinoma.

Funder

National Natural Science Foundation of China

Youth Innovation Promotion Association

Chinese Academy of Sciences

3315 Innovation Team in Ningbo City

Publisher

Royal Society of Chemistry (RSC)

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