Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis-Reference-Cited by-同舟云学术

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

Published:2011 Issue:19 Volume:47 Page:5452-5454
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ryan Chris P.¹²³⁴,Smith Mark E. B.¹²³⁴,Schumacher Felix F.¹²³⁴,Grohmann Dina⁵²⁶⁴,Papaioannou Danai⁷⁸⁴,Waksman Gabriel⁷⁸⁴,Werner Finn⁵²⁶⁴,Baker James R.¹²³⁴,Caddick Stephen¹²³⁴

Affiliation:

1. Department of Chemistry

2. University College London

3. London WC1H 0AJ

4. UK

5. Research Department of Structural and Molecular Biology

6. London WC1E 6BT

7. Institute of Structural and Molecular Biology at UCL/Birkbeck

8. London WC1E 7HX

Abstract

Controlling maleimide hydrolysis allows the modular construction of bromomaleimide-mediated bioconjugates which are either stable or cleavable in an aqueous, thiol-mediated reducing environment.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2011/CC/C1CC11114K

Reference19 articles.

1. Expanding the diversity of chemical protein modification allows post-translational mimicry

2. Mimicking Posttranslational Modifications of Proteins

3. Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation

4. Design, synthesis and biological application of chemical probes for bio-imaging

5. Fluorescent Probes and Delivery Methods for Single-Molecule Experiments

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