Extension of hydrogen borrowing alkylation reactions for the total synthesis of (−)-γ-lycorane-Reference-Cited by-同舟云学术

Extension of hydrogen borrowing alkylation reactions for the total synthesis of (−)-γ-lycorane

Published:2022 Issue:32 Volume:58 Page:4966-4968
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hall Christopher J. J.¹,Marriott Indi S.¹,Christensen Kirsten E.¹,Day Aaron J.¹,Goundry William R. F.²,Donohoe Timothy J.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK

2. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield, UK

Abstract

The total synthesis of (–)-γ-lycorane (10 steps) was completed from cyclohexenone. This is one of the first examples of hydrogen borrowing C–C bond formation being used as a key step in a total synthesis project.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC01248K

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