Ligand binding of interleukin-8: a comparison of glycosaminoglycans and acidic peptides-Reference-Cited by-同舟云学术

Ligand binding of interleukin-8: a comparison of glycosaminoglycans and acidic peptides

Published:2023 Issue:36 Volume:25 Page:24930-24947
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Schulze Christian¹,Danielsson Annemarie²^ORCID,Liwo Adam²^ORCID,Huster Daniel¹^ORCID,Samsonov Sergey A.²^ORCID,Penk Anja¹^ORCID

Affiliation:

1. Institute for Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16/18, 04107 Leipzig, Germany

2. Faculty of Chemistry, University of Gdańsk, Fahrenheit Union of Universities, ul. Wita Stwosza 63, 80-308 Gdańsk, Poland

Abstract

The binding of acidic peptides with varying charge density is compared with the binding of glycosaminoglycans to IL-8. While binding epitopes are similar, the affinity significantly differs even if peptide and sugar have the same charge density.

Funder

Deutsche Forschungsgemeinschaft

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CP/D3CP02457A

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