Ligand binding of interleukin-8: a comparison of glycosaminoglycans and acidic peptides

Author:

Schulze Christian1,Danielsson Annemarie2ORCID,Liwo Adam2ORCID,Huster Daniel1ORCID,Samsonov Sergey A.2ORCID,Penk Anja1ORCID

Affiliation:

1. Institute for Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16/18, 04107 Leipzig, Germany

2. Faculty of Chemistry, University of Gdańsk, Fahrenheit Union of Universities, ul. Wita Stwosza 63, 80-308 Gdańsk, Poland

Abstract

The binding of acidic peptides with varying charge density is compared with the binding of glycosaminoglycans to IL-8. While binding epitopes are similar, the affinity significantly differs even if peptide and sugar have the same charge density.

Funder

Deutsche Forschungsgemeinschaft

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Reference85 articles.

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2. New methods to study the composition and structure of the extracellular matrix in natural and bioengineered tissues

3. Sulfation pattern in glycosaminoglycan: Does it have a code?

4. Fell–Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra

5. Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

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