2-Aryl-1-hydroxyimidazoles possessing antiviral activity against a wide range of orthopoxviruses, including the variola virus

Author:

Basanova Elizaveta I.1ORCID,Kulikova Ekaterina A.1,Bormotov Nikolai I.2,Serova Olga A.2,Shishkina Larisa N.2,Ovchinnikova Alyona S.2,Odnoshevskiy Dmitry A.2,Pyankov Oleg V.2,Agafonov Alexander P.2,Yarovaya Olga I.3,Borisevich Sophia S.4,Ilyina Margarita G.4,Kolybalov Dmitry S.5ORCID,Arkhipov Sergey G.5ORCID,Bogdanov Nikita E.56,Pavlova Marina A.7ORCID,Salakhutdinov Nariman F.3,Perevalov Valery P.1,Nikitina Polina A.1

Affiliation:

1. Department of Fine Organic Synthesis and Chemistry of Dyes, D.I. Mendeleev University of Chemical Technology of Russia, Miusskaya sq., 9, 125047, Moscow, Russia

2. State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559, Koltsovo, Russia

3. Department of Medicinal Chemistry, N.N. Vorozhtsov Institute of Organic Chemistry SB RAS, Lavrentyev Ave., 9, 630090, Novosibirsk, Russia

4. SRF “SKIF”, 630559, Koltsovo, Russia

5. Scientific Educational Center “Institute of Chemical Technology”, Novosibirsk State University, Pirogova str., 1, 630090, Novosibirsk, Russia

6. V.S. Sobolev Institute of Geology and Mineralogy, Siberian Branch of Russian Academy of Sciences, Koptyuga Ave., 3, 630090 Novosibirsk, Russia

7. Laboratory of Photoactive Supramolecular Systems, A.N. Nesmeyanov Institute of Organoelement Compounds RAS, Vavilova str., 28, 119991, Moscow, Russia

Abstract

Newly synthesized 2-aryl-1-hydroxyimidazoles display promising antiviral activity against orthopoxviruses, including the variola virus.

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

Royal Society of Chemistry (RSC)

Reference44 articles.

1. “Virus Taxonomy: 2022 release” International Committee on Taxonomy of Viruses (ICTV), https://ictv.global/taxonomy , (accessed October 2023)

2. World Health Organization , Smallpox , https://www.who.int/health-topics/smallpox#tab=tab_1 , (accessed October 2023)

3. The Transmission Potential of Monkeypox Virus in Human Populations

4. The changing epidemiology of human monkeypox—A potential threat? A systematic review

5. The Threat of Synthetic Smallpox: European Perspectives

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