A perfluoroaromatic abiotic analog of H2 relaxin enabled by rapid flow-based peptide synthesis-Reference-Cited by-同舟云学术

A perfluoroaromatic abiotic analog of H2 relaxin enabled by rapid flow-based peptide synthesis

Published:2016 Issue:13 Volume:14 Page:3345-3349
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lühmann Tessa¹²³⁴⁵,Mong Surin K.¹²³⁴,Simon Mark D.¹²³⁴,Meinel Lorenz⁵⁶⁷⁸,Pentelute Bradley L.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Massachusetts Institute of Technology

3. Cambridge

4. USA

5. Institute of Pharmacy and Food Chemistry

6. University of Wurzburg

7. Wurzburg

8. Germany

Abstract

We report on the rapid-flow based synthesis and functional characterization of a H2 relaxin analog that takes advantage of perfluoroarylation-cysteine SNAr chemistry for a disulfide replacement strategy.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00208K

Reference29 articles.

1. The Relaxin Peptide Family – Structure, Function and Clinical Applications

2. Activation of Orphan Receptors by the Hormone Relaxin

3. International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides

4. Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin

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