An oral pH-activated “nano-bomb” carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative colitis-Reference-Cited by-同舟云学术

An oral pH-activated “nano-bomb” carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative colitis

Published:2022 Issue: Volume: Page:
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Yang Mei¹²,Yang Chunhua³^ORCID,Zhang Yujie¹²,Yan Xiangji¹²,Ma Yana¹²,Zhang Yuanyuan¹²,Cao Yameng¹²,Xu Qiuran⁴⁵,Tu Kangsheng⁶,Zhang Mingzhen¹²^ORCID

Affiliation:

1. School of Basic Medical Sciences, Xi'an Key Laboratory of Immune Related Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China

2. Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi, 710061, China

3. Institute for Biomedical Sciences, Center for Diagnostics and Therapeutics, Digestive Disease Research Group, Georgia State University, Atlanta, Georgia, 30302, USA

4. Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China

5. Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Hangzhou, Zhejiang, 310009, China

6. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China

Abstract

A pH-activated nano-bomb carrier with endo/lysosomal escape capability enhanced the delivery of siCD98, and when combined with berberine it enhanced the therapeutic effect on ulcerative colitis through anti-inflammation and restoring gut microbiota.

Funder

National Natural Science Foundation of China

Shaanxi Key Science and Technology Innovation Team Project

Natural Science Foundation of Zhejiang Province

Xi’an Jiaotong University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D1BM01765A

Reference64 articles.