Synthesis of 7-hydroxy-6,7-dihydro-indole and 6′,7′-dihydro-3,7′-biindole derivatives from domino reactions of arylglyoxals or methyl ketones with enamines-Reference-Cited by-同舟云学术

Synthesis of 7-hydroxy-6,7-dihydro-indole and 6′,7′-dihydro-3,7′-biindole derivatives from domino reactions of arylglyoxals or methyl ketones with enamines

Published:2015 Issue:64 Volume:5 Page:51501-51507
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lu Xin-Mou¹²³⁴⁵,Cai Zhong-Jian¹²³⁴⁵,Li Jian¹²³⁴⁵,Wang Shun-Yi¹²³⁴⁵,Ji Shun-Jun¹²³⁴⁵

Affiliation:

1. Key Laboratory of Organic Synthesis of Jiangsu Province

2. College of Chemistry

3. Chemical Engineering and Materials Science

4. Soochow University

5. Suzhou 215123

Abstract

A series of interesting 7-hydroxy-2-aryl-6,7-dihydro-indol-4(5H)-ones 3 was successfully synthesized in moderate to good yields by the domino reactions of different arylglyoxals 1 with enamines 2 under catalyst-free conditions.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA09478J

Reference25 articles.

1. A practical and efficient route for synthesis of 6-aminomethyl-4-oxo-4,5,6,7-tetrahydroindoles as new CNS agent precursors

2. Synthesis and in vitro cytotoxic activity of pyrrolo[2,3-e]indole derivatives and a dihydro benzoindole analogue

3. Anti-tumour heterocycles. Part xiv. A new route to pyrrolo-[3,2-f]indoles and the novel pyrrolo[3,2-f; 4,5-f′]diindole system

4. BIOTRANSFORMATION OF A GABAARECEPTOR PARTIAL AGONIST IN SPRAGUE-DAWLEY RATS AND CYNOMOLGUS MONKEYS: IDENTIFICATION OF TWO UNIQUEN-CARBAMOYL METABOLITES

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