An ion mobility-mass spectrometry study of copper-metallothionein-2A: binding sites and stabilities of Cu-MT and mixed metal Cu–Ag and Cu

An ion mobility-mass spectrometry study of copper-metallothionein-2A: binding sites and stabilities of Cu-MT and mixed metal Cu–Ag and Cu–Cd complexes

Published:2023 Issue:3 Volume:148 Page:546-555
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Fan Liqi¹,Russell David H.¹^ORCID

Affiliation:

1. Department of Chemistry, Texas A&M University, College Station, TX 77843, USA

Abstract

Cu(i) binds to human metallothionein MT2 to form stable Cu6- and Cu10-MT complexes that exhibit high gas-phase stabilities.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/AN/D2AN01556K

Reference53 articles.

1. Combining Chemical Labeling, Bottom-Up and Top-Down Ion-Mobility Mass Spectrometry To Identify Metal-Binding Sites of Partially Metalated Metallothionein

2. Metal-Induced Conformational Changes of Human Metallothionein-2A: A Combined Theoretical and Experimental Study of Metal-Free and Partially Metalated Intermediates

3. Metallothioneins: unparalleled diversity in structures and functions for metal ion homeostasis and more

4. State-of-the-art of metallothioneins at the beginning of the 21st century

5. Assessment of metals in reconstituted metallothioneins by electrospray mass spectrometry

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