Investigating the properties of <scp>l</scp>-lysine dendrimers through physico-chemical characterisation techniques and atomistic molecular dynamics simulations-Reference-Cited by-同舟云学术

Investigating the properties of l-lysine dendrimers through physico-chemical characterisation techniques and atomistic molecular dynamics simulations

Published:2022 Issue:18 Volume:13 Page:2626-2636
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

England R. M.¹^ORCID,Sonzini S.²^ORCID,Buttar D.³^ORCID,Treacher K. E.⁴^ORCID,Ashford M. B.¹^ORCID

Affiliation:

1. Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield, UK

2. Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Cambridge, UK

3. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield, UK

4. New Modalities Product Development, Pharmaceutical Technology and Development, Operations, AstraZeneca, Macclesfield, UK

Abstract

Poly(l-lysine) dendrimers up to generation 6 have been analysed by SEC, Taylor dispersion analysis and atomistic molecular dynamics simulations to determine their properties, in what could be considered an understudied dendrimer series.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/PY/D2PY00080F

Reference63 articles.

1. E.Buhleier , W.Wehner and F.Vögtle , Synthesis , 1978 2 155158

2. Micelles. Part 1. Cascade molecules: a new approach to micelles. A [27]-arborol

3. A New Class of Polymers: Starburst-Dendritic Macromolecules

4. Peptide dendrimers: applications and synthesis

5. Peptide and Amide Bond-Containing Dendrimers

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