Probing the effect of minor groove interactions on the catalytic efficiency of DNAzymes 8–17 and 10–23

Abstract

An adenosine analog devoid of the N3-nitrogen of the purine ring was incorporated into the catalytic cores of the well-known DNA enzymes 8–17 and 10–23. The results show that minor groove interactions are important for the catalytic activity and thus constitute an important feature of DNA enzymes.