Catalyst- and additive-free [3 + 3] cyclization–aromatization of β,γ-dioxobutanoate with amines for synthesis of <i>p</i>-aminophenols-Reference-Cited by-同舟云学术

Catalyst- and additive-free [3 + 3] cyclization–aromatization of β,γ-dioxobutanoate with amines for synthesis of p-aminophenols

Published:2022 Issue:24 Volume:24 Page:9690-9696
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Qian Hang¹,Wang Cui-Cui¹,Shen Zi-Chen¹,Sun Ming-Xue¹,Zhang Hong-Chao¹,Fan Shiming¹,Feng Juan¹,Liu Shouxin¹,Zhang Zhi-Wei¹^ORCID

Affiliation:

1. College of Chemical & Pharmaceutical Engineering, State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Hebei University of Science & Technology, Shijiazhuang 050018, P. R. China

Abstract

A [3 + 3] cyclization–aromatization of β,γ-dioxobutanoate with amines for synthesis of p-aminophenols under catalyst- and additive-free conditions was developed. The reaction displays high efficiency in the late-stage modification of drug molecules.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hebei Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/GC/D2GC03936B

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